The Mission guides Europe's transition to climate neutrality by supporting 100 cities in the EU and 12 cities in Horizon Europe associated countries in their efforts to achieve climate neutrality by 2030. Selected from 377 applications, these cities serve as innovation hubs, experimenting with cross-sectoral solutions and new governance models to accelerate change and inspire all European cities to follow suit by 2050.

At the heart of the Mission are the Climate City Contracts, created in collaboration with local stakeholders and citizens, which outline each city's roadmap to climate neutrality, including plans for energy, buildings, waste management, and transport, along with related investment plans. Cities that successfully develop these contracts receive the EU Mission Label, recognition that facilitates access to public and private funding.

Prato, Rome, Parma, and Bergamo are among the 9 Italian cities that are part of the 100 selected European cities and have been awarded the Mission Label.